From the West:

If you are coming from Witchita, Kansas City, St. Louis and Nashville, take I-70 to I-64 (through St. Louis). Continue I-64 to I-57 to I-24 and the I-40 east (through Nashville). Stay on I-40 east and exit 364 S.R. 95. Go east on 321 through Maryville and Townsend. where you enter the Park from the Townsend side of the Smokies, near Cades Cove.