Great Smoky Mountains National Park Directions
Map Directions to the Smokies from the US
Southeast 
If you are coming from Tampa, Montgomery, Birmingham,
Macon, Atlanta and Chattanooga, the quickest route is to take I-75
to exit 81 (S.R.95). Go east on 321 through Maryville and Townsend.
where you enter the Park from the Townsend entrance, near Cades Cove.
Optionally, if you are in the upper reaches of Georgia and North Carolina,
you can enter the Park at the south entrance at Cherokee, NC via 441
at Dillsboro.
If you are coming from Charleston, Columbia, Greenville, Spartanburg, Asheville, Jacksonville, Miami and Daytona Beach, take I-26 to I-40 west and the Foothills Parkway exit 443. Turn left onto U.S. 321. Follow U.S. 321 until you reach Gatlinburg. Continue through Gatlinburg. From light #1, it is less than a mile to the Park entrance and the Sugarland Visitors Center.