From the Northeast:

If you are coming from Harrisburg and Roanoke, take I-81 south to I-40 east. Take I-40 to Wilton Springs/U.S. 321 south and west exit 440. Turn right and follow U.S. 321 into Gatlinburg. From light #1, it is less than a mile to the Park entrance and the Sugarland Visitors Center.

If you are coming from Baltimore and Washington D.C., take I-66 to I-81 southand then to I-40 east. Take I-40 to Wilton Springs/U.S. 321 south and west exit 440. Turn right and follow U.S. 321 into Gatlinburg. From light #1, its less than a mile to the Park entrance and the Sugarland Visitors Center.