From the North:

If you're coming fromIndianapolis, Detroit, Cincinnati or Lexington, take I-75 toward Knoxville. Take I-40 eastbound to exit 407. Turn right onto S.R. 66. Continue until the first major intersection in Sevierville. Turn left onto U.S. 411 and follow 411 to S.R. 416. Turn right on S.R. 416 and follow until you reach U.S. 321. Turn right onto U.S. 321 south and west and continue until you reach Gatlinburg. Continue through Gatlinburg. From light #1, it is less than a mile to the Park entrance and the Sugarland Visitors Center.